Retatrutide is a new weekly weight loss injection that’s still in development. Like other popular GLP-1s, it helps you feel full so you naturally eat less.
The difference is in how it works. Retatrutide has been nicknamed “Triple G” because it activates three key hormones at once: GLP-1, GIP, and GCG (glucagon). This triple effect may make it the most powerful option yet and early studies back that up.
In a phase II trial, people lost an average of 24.2% of their body weight in just 48 weeks at the highest dose. That’s more than the results seen with Wegovy (~14.9% at 68 weeks) or Mounjaro (~21% at 72 weeks).
